Time-independent disease state identification defines distinct trajectories determined by localised vs systemic inflammation in patients with early rheumatoid arthritis
Published in Ann Rheum Dis, 2025
Patients with rheumatoid arthritis (RA) display different trajectories towards improvement of disease. We aimed to disentangle the heterogeneity of RA disease trajectories from the first clinical visit onwards using graph-based pseudotime analysis.
Recommended citation: Steinz N, Maarseveen TD, van den Akker EB, Cope AP, Isaacs JD, Winkler AR, Huizinga TWJ, Abraham Y, Knevel R. (2025) "Time-independent disease state identification defines distinct trajectories determined by localised vs systemic inflammation in patients with early rheumatoid arthritis" Ann Rheum Dis. 2025 Aug;84(8):1301-1312. doi: 10.1016/j.ard.2025.04.011. Epub 2025 May 9.
Recommended citation: Steinz N, Maarseveen TD, van den Akker EB, Cope AP, Isaacs JD, Winkler AR, Huizinga TWJ, Abraham Y, Knevel R. (2025) "Time-independent disease state identification defines distinct trajectories determined by localised vs systemic inflammation in patients with early rheumatoid arthritis" Ann Rheum Dis. 2025 Aug;84(8):1301-1312. doi: 10.1016/j.ard.2025.04.011. Epub 2025 May 9.
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